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MPHOSPH8 [nucleoplasm]
Stable Identifier
R-HSA-9844052
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
M-phase phosphoprotein 8, MPP8_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
HUSH complex binds LINE1 (L1) RNA (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
NEXT complex:HUSH complex:L1HS:L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex:L1 RNA [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex [nucleoplasm] (Homo sapiens)
MPHOSPH8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99549 MPHOSPH8
Gene Names
MPHOSPH8, MPP8
Chain
chain:1-860
Reference Genes
BioGPS Gene:54737 MPHOSPH8
COSMIC (genes):MPHOSPH8 MPHOSPH8
CTD Gene:54737 MPHOSPH8
dbSNP Gene:54737 MPHOSPH8
ENSEMBL:ENSG00000196199 MPHOSPH8
HGNC:29810 MPHOSPH8
Monarch:54737 MPHOSPH8
NCBI Gene:54737 MPHOSPH8
OMIM:611626 MPHOSPH8
UCSC:Q99549 MPHOSPH8
Reference Transcript
RefSeq:NM_017520.3 MPHOSPH8
Other Identifiers
11734842_at
11734843_x_at
11734844_a_at
11746112_x_at
11763450_s_at
16772904
221771_PM_s_at
221771_s_at
225041_PM_at
225041_at
227026_PM_at
227026_at
3442692
3442693
3442694
3442695
3442696
3442698
3480021
3480022
3480023
3480024
3480025
3480032
3480033
3480034
3480035
3480038
3480042
3480043
3480044
3480045
3480046
3480047
3480048
3480049
3480050
3480052
3480054
3480056
3480057
3480060
3480061
3480062
3480063
3480064
3480065
3480066
3480067
3480068
3480079
35110_at
54737
57834_at
7967881
90596_at
A_14_P132052
A_14_P200363
A_23_P204967
A_24_P188183
A_24_P287403
GE85979
GO:0000786
GO:0000792
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0006325
GO:0035064
GO:0042393
GO:0043226
GO:0044027
GO:0045814
GO:0045869
GO:0060090
GO:0090309
GO:0140566
HMNXSV003007957
Hs.244482.0.S1_3p_at
Hs.244482.1.A1_3p_at
Hs.244482.1.A2_3p_a_at
ILMN_2054213
PH_hs_0024869
TC13000017.hg
Participates
as a component of
HUSH complex [nucleoplasm] (Homo sapiens)
Inferred To
MPHOSPH8 [nucleoplasm]
(Bos taurus)
MPHOSPH8 [nucleoplasm]
(Gallus gallus)
Ghost homologue of MPHOSPH8 [nucleoplasm]
(Canis familiaris)
Ghost homologue of MPHOSPH8 [nucleoplasm]
(Sus scrofa)
ankrd46 [nucleoplasm]
(Danio rerio)
ankrd46a [nucleoplasm]
(Danio rerio)
Homologues of MPHOSPH8 [nucleoplasm]
(Danio rerio)
Mphosph8 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000361479
,
ENSP00000355388
OpenTargets
ENSG00000196199
HPA
ENSG00000196199-MPHOSPH8
PRO
Q99549
Pharos - Targets
Q99549
PDB
6V2S
,
3QO2
,
3R93
,
7M5U
,
3LWE
,
3SVM
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.564
3
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