NICD1 binds the NFE2L2 promoter

Stable Identifier
R-HSA-9762102
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NICD1 binds the NFE2L2 promoter
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NICD1, the NOTCH1 intracellular domain, binds to its cognate site in the promoter of the NFE2L2 gene as assessed by electrophoretic mobility shift assay and chromatin immunoprecipitation (Wakabayashi et al, 2014). NFE2L2 is implicated in the progression of a number of cancers, supporting proliferation through metabolic reprogramming into the pentose phosphate pathway, and by increasing the antioxidant and detoxifying abilities of the cells (reviewed in He et al, 2020; Kitamura and Motohashi, 2018).

Literature References
PubMed ID Title Journal Year
29450944 NRF2 addiction in cancer cells

Motohashi, H, Kitamura, H

Cancer Sci 2018
24298019 Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling

Palliyaguru, DL, Fujimuro, M, Noda, K, Kimura, S, Slocum, SL, Shigemura, N, Chartoumpekis, DV, Tanaka, Y, Boley, PA, Yamamoto, M, Wakabayashi, N, Biswal, S, Skoko, JJ, Kensler, TW

Mol Cell Biol 2014
32640524 NRF2, a Transcription Factor for Stress Response and Beyond

He, F, Wen, T, Ru, X

Int J Mol Sci 2020
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-17)
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