MYC- and NICD1-dependent NFE2L2 gene expression

Stable Identifier
R-HSA-9762100
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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MYC- and NICD1-dependent NFE2L2 gene expression
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Oncogene-dependent upregulation of NFE2L2 expression has been shown to contribute to a number of cancers (Best et al, 2021; Tang et al, 2017; De Nicola et al, 2011; Mitsuishi et al, 2012; Wakabayashi et al, 2014; reviewed in He et al, 2020; Kitamura and Motohashi, 2018). Elevated NFE2L2 levels contribute to metabolic reprogramming, notably diverting carbon metabolism into the pentose phosphate pathway (PPP). PPP generates NADPH and intermediates that are needed for the synthesis of sterols, fatty acids and nucleic acids, and thereby supports proliferative growth and maintenance of redox balance (reviewed in Ge et al, 2020; Hayes et al, 2020).
Literature References
PubMed ID Title Journal Year
32649885 Oxidative Stress in Cancer

Hayes, JD, Dinkova-Kostova, AT, Tew, KD

Cancer Cell 2020
29450944 NRF2 addiction in cancer cells

Kitamura, H, Motohashi, H

Cancer Sci 2018
21734707 Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, GM, Karreth, FA, Humpton, TJ, Gopinathan, A, Wei, C, Frese, K, Mangal, D, Yu, KH, Yeo, CJ, Calhoun, ES, Scrimieri, F, Winter, JM, Hruban, RH, Iacobuzio-Donahue, C, Kern, SE, Blair, IA, Tuveson, DA

Nature 2011
33859744 c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Tang, YC, Hsiao, JR, Jiang, SS, Chang, JY, Chu, PY, Liu, KJ, Fang, HL, Lin, LM, Chen, HH, Huang, YW, Chen, YT, Tsai, FY, Lin, SF, Chuang, YJ, Kuo, CC

Theranostics 2021
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Mitsuishi, Y, Taguchi, K, Kawatani, Y, Shibata, T, Nukiwa, T, Aburatani, H, Yamamoto, M, Motohashi, H

Cancer Cell 2012
24298019 Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling

Wakabayashi, N, Skoko, JJ, Chartoumpekis, DV, Kimura, S, Slocum, SL, Noda, K, Palliyaguru, DL, Fujimuro, M, Boley, PA, Tanaka, Y, Shigemura, N, Biswal, S, Yamamoto, M, Kensler, TW

Mol Cell Biol 2014
32582032 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Ge, T, Yang, J, Zhou, S, Wang, Y, Li, Y, Tong, X

Front Endocrinol (Lausanne) 2020
32640524 NRF2, a Transcription Factor for Stress Response and Beyond

He, F, Ru, X, Wen, T

Int J Mol Sci 2020
29526543 Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Best, SA, De Souza, DP, Kersbergen, A, Policheni, AN, Dayalan, S, Tull, D, Rathi, V, Gray, DH, Ritchie, ME, McConville, MJ, Sutherland, KD

Cell Metab 2018
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NFE2L2 gene:NICD1 [nucleoplasm] (Homo sapiens)
Active Unit
NICD1 [nucleoplasm]
Regulator
NFE2L2 gene:MYC [nucleoplasm] (Homo sapiens)
Active Unit
MYC [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-17)
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