NFE2L2-dependent ME1 gene expression

Stable Identifier
R-HSA-9761854
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NFE2L2-dependent ME1 gene expression
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ME1 encodes malic enzyme 1, the cytosolic protein that catalyzes the decarboxylation of malate to pyruvate, generating NADPH. ME1 is a key enzyme in the redox balance of the cell, contributes to fatty acid, cholesterol and lipid biosynthesis through the production of NADPH and regulates the flow of carbon through various carbon metabolic pathways inlcuding glycolysis, the citric acid cycle and the aerobic glycolysis of pyruvate to lactate that is characteristic of the Warburg effect (reviewed in Simmen et al, 2020).
The ME1 gene has been shown to be a direct target of the NFE2L2 pathway, a key regulator of the anti-oxidant response pathway (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Motohashi, H, Yamamoto, M, Nukiwa, T, Aburatani, H, Kawatani, Y, Shibata, T, Mitsuishi, Y, Taguchi, K

Cancer Cell 2012
33064660 Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism

Simmen, RCM, Alhallak, I, Simmen, FA

J Mol Endocrinol 2020
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
ME1 gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-15)
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