NFE2L2-dependent TKT gene expression

Stable Identifier
R-HSA-9761852
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NFE2L2-dependent TKT gene expression
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Transketolase (TKT) encodes an enzyme responsible for two reversible reactions of the non-oxidative branch of the pentose phosphate pathway (PPP). The PPP branches off from glycolysis and diverts carbon metabolites into other biosynthetic pathways to generate NADPH, fatty acids, sterols and nucleic acids, among others (reviewed in Ge et al, 2020). NFE2L2 is a transcription factor with key roles in antioxidant response, redox balance, NADPH generation and metabolic reprogramming, including during oncogenesis (reviewed in Baird and Yamamoto, 2020; Ge et al, 2020; Smolkova et al 2020). NFE2L2 binds as a heterodimer with a member of the MAF protein family to antioxidant response elements in the promoters of target genes, including TKT and other enzymes in the PPP (Tang et al, 2021; reviewed in Baird and Yamamoto; Ge et al, 2020).
Literature References
PubMed ID Title Journal Year
33859744 c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Chu, PY, Chen, HH, Lin, LM, Chang, JY, Lin, SF, Chen, YT, Liu, KJ, Huang, YW, Chuang, YJ, Kuo, CC, Tsai, FY, Fang, HL, Hsiao, JR, Jiang, SS, Tang, YC

Theranostics 2021
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
31989830 Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism

Leguina-Ruzzi, A, Bai, P, Smolková, K, Kovács, T, Sipos, A, Mikó, E

Antioxid Redox Signal 2020
32582032 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Ge, T, Yang, J, Tong, X, Wang, Y, Zhou, S, Li, Y

Front Endocrinol (Lausanne) 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TKT gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-15)
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