AMOT-2 binds CDH11

Stable Identifier
R-HSA-9761474
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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AMOT-2 binds CDH11
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Angiomotin (AMOT) isoform p80 (AMOT-2) binds to CDH11 C-terminal binding sequence (CBS). The CBS motif of CDH11 that binds AMOT-2 does not overlap with the CBS motif that binds CTNNB1 (beta-catenin). The two CBS motifs are 40 amino acid residues apart, but it is uncertain if there is any steric hindrance between simultaneous binding of CTNNB1 and AMOT-2 to CDH11. AMOT-2 binding to CDH11 appears to stimulate CDH11-mediated cell migration. AMOT-2 has been implicated as a promoter of tumorigenesis in previous studies (Levchenko et al. 2004; Jiang et al. 2006; Yi et al. 2011, Ortiz et al. 2015). AMOT was identified as a CDH11 interactor in the high-throughput screen conducted by Lee et al. 2018.
Literature References
PubMed ID Title Journal Year
25466890 Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration

Liu, HC, Lin, SH, Bilen, MA, Yu, G, Lee, YC, Cho, H, Lin, SC, Yu-Lee, LY, Ortiz, A

FASEB J 2015
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Orthologous Events
AMOT-2 binds CDH11 (Bos taurus)
AMOT-2 binds CDH11 (Canis familiaris)
AMOT-2 binds CDH11 (Gallus gallus)
AMOT-2 binds CDH11 (Mus musculus)
AMOT-2 binds CDH11 (Rattus norvegicus)
AMOT-2 binds CDH11 (Sus scrofa)
AMOT-2 binds CDH11 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-01-14)
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