Reactome | AMOT-2 [cytosol]

AMOT-2 [cytosol]

Stable Identifier

R-HSA-9761473

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMOT-p80, Angiomotin-p80

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 function (Homo sapiens)
        
        AMOT-2 binds CDH11 (Homo sapiens)
        
        AMOT-2 [cytosol] (Homo sapiens)
        
        CDH11:CTNND1:CTNNB1:AMOT-2 [plasma membrane] (Homo sapiens)
        
        AMOT-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q4VCS5-2 AMOT

Gene Names

AMOT, KIAA1071

Other Identifiers

11739349_a_at

11739350_a_at

11739351_a_at

11752551_a_at

154796

17113418

209521_PM_s_at

209521_s_at

38286_at

4018455

4018456

4018457

4018458

4018459

4018460

4018461

4018462

4018463

4018464

4018465

4018468

4018469

4018470

4018474

4018479

4018481

4018483

4018484

4018485

4018486

4018487

4018488

4018489

4018492

4018497

4018498

4018499

4018505

4018507

4018511

8174576

A_23_P171232

A_24_P344961

A_33_P3347397

GE53727

GE84434

GO:0001525

GO:0001570

GO:0001701

GO:0001702

GO:0001725

GO:0001726

GO:0003013

GO:0003365

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005923

GO:0006935

GO:0007010

GO:0007043

GO:0007163

GO:0008104

GO:0008180

GO:0009897

GO:0009986

GO:0016020

GO:0016525

GO:0023052

GO:0030027

GO:0030036

GO:0030054

GO:0030139

GO:0030154

GO:0030334

GO:0031410

GO:0034330

GO:0035329

GO:0038023

GO:0040019

GO:0042074

GO:0043116

GO:0043226

GO:0043532

GO:0043534

GO:0043536

GO:0045793

GO:0048514

GO:0048856

GO:0048870

GO:0051056

GO:0051496

GO:0060089

GO:0070161

GO:0090162

HMNXSV003019605

HMNXSV003047904

ILMN_1792409

PH_hs_0000969

TC0X001286.hg

g9887325_3p_a_at

Participates

as a component of

CDH11:CTNND1:CTNNB1:AMOT-2 [plasma membrane] (Homo sapiens)

as an input of

AMOT-2 binds CDH11 (Homo sapiens)

Inferred To

Amot [cytosol] (Mus musculus)

Amot [cytosol] (Rattus norvegicus)

AMOT [cytosol] (Bos taurus)

AMOT [cytosol] (Canis familiaris)

AMOT [cytosol] (Gallus gallus)

AMOT [cytosol] (Sus scrofa)

amot [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001106962.1, XP_005262147.1, NP_573572.1, XP_016884778.1, XP_011529177.1, XP_005262144.1

OpenTargets

ENSG00000126016

HPA

ENSG00000126016-AMOT

GeneCards

Q4VCS5

Ensembl

ENSP00000361027, ENST00000371959, ENSG00000126016, ENST00000304758, ENSP00000305557

PRO

Q4VCS5

Pharos - Targets

Q4VCS5

PDB

7NMA, 7LP5, 7NND, 7OQS, 7LP2, 7NMX, 7NPG, 7OQJ, 6JJX, 7OQW, 7NP2, 7NPB, 7LP3, 7NNE, 7OQU, 7OQG, 7NMW, 7NN2

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.882	10
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.802	6
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.802	7
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.615	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	2
UniProt:Q96PU5 NEDD4L	2	NEDD4L [cytosol] (R-HSA-976003) NEDD4L [nucleoplasm] (R-HSA-2176420)	0.527	2
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.527	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.499	3
UniProt:P46662	1	Nf2 [plasma membrane] (R-MMU-5669168)	0.499	2