Regulation of CDH11 function

Stable Identifier
Homo sapiens
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Like other classical cadherins, CDH11 associates with several catenin proteins through its intracellular domain, which is thought to play a role in the establishment and regulation of adherens junctions. These catenin proteins include CTNND1 (also known as p120 catenin or delta-catenin), CTNNB1 (beta-catenin), JUP (Junction Plakoglobin, also known as gamma-catenin), and CTNNA1 (alpha-catenin) (Straub et al. 2003; Kiener et al. 2006; Ortiz et al. 2015; Lee et al. 2018).

CDH11, through its C terminus, also forms a complex with angiomotin (AMOT) isoform p80 (AMOT-2), which is implicated in CDH11-mediated cell migration and tumor cell invasiveness (Levchenko et al. 2004; Jiang et al. 2006; Yi et al. 2011; Ortiz et al. 2015; Lee et al. 2018).

Through its extracellular region, CDH11 binds to the C terminal fragment of ANGPTL4 (Angiopoietin-like-4), commonly known as cANGPTL4, which is implicated in the regulation of wound healing. The variant isoform of CDH11 (CDH11v), an 85 kDa membrane-bound protein produced as a result of alternative splicing (Kawaguchi et al. 1999), can compete with the canonical CDH11 for cANGPTL4 binding (Teo et al. 2017).
Literature References
PubMed ID Title Journal Year
14625392 A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells

Spring, H, Schnoelzer, M, Kuhn, C, Korf, U, Boda, J, Hatzfeld, M, Franke, WW, Straub, BK, Kempf, T

J Cell Sci 2003
14730344 Angiomotin expression promotes hemangioendothelioma invasion

Bratt, A, Holmgren, L, Levchenko, T, Arbiser, JL

Oncogene 2004
21481793 A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions

Shimono, A, Yi, C, Kissil, JL, Avila, JL, Stemmer-Rachamimov, A, Persson, NL, Marmorstein, R, Fera, D, Christian, N, Holmgren, L, Troutman, S, Speicher, DW

Cancer Cell 2011
25466890 Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration

Liu, HC, Lin, SH, Bilen, MA, Yu, G, Lee, YC, Cho, H, Lin, SC, Yu-Lee, LY, Ortiz, A

FASEB J 2015
16430777 Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer

Watkins, G, Mansel, RE, Jiang, WG, Holmgren, L, Douglas-Jones, A

BMC Cancer 2006
16525026 The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility

Kiener, HP, Allen, PG, Stipp, CS, Higgins, JM, Brenner, MB

Mol Biol Cell 2006
10320525 Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11

Machinami, R, Takeshita, S, Kawaguchi, J, Kashima, T, Imai, T, Kudo, A

J Bone Miner Res 1999
29110486 Impact of Detergents on Membrane Protein Complex Isolation

Sachan, N, Martinez, J, Li, S, Lee, YC, Kürten, C, Sarr, M, Gamero-Estevez, E, Subramanian, N, Dornan, M, Bååth, JA, Kernan, J, Shan, X, Rivera, K, Pappin, D, Lin, SH, Cantoria, MJ, Ford, L, Halova, L, Bastle, RM, Bhattacharjee, S

J Proteome Res 2018
28740178 Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression

Teo, DJR, Sng, MK, Teo, Z, Zhu, P, Chong, HC, Tan, NS, Chan, JSK, Wong, MTC, Phua, GZM, Choo, CC, Choong, C

Sci Rep 2017
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