CDH11 gene is transcribed into nascent CDH11 mRNA

Stable Identifier
R-HSA-9760965
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CDH11 gene is transcribed into nascent CDH11 mRNA
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Transcription of the CDH11 gene is governed by several transcription factors.

ILF3 and HOXC8 transcription factors, stimulate CDH11 transcription both individually and cooperatively, through complex formation (Lei et al. 2005, Lei et al. 2006, Li et al. 2014, Zhang et al. 2017).

ZEB2 stimulates CDH11 transcription in an SP1-dependent manner, which is thought to contribute to epithelial-to-mesenchymal transition (EMT) (Nam et al. 2014).

HEYL directly stimulates CDH11 gene transcription. Both HEYL and CDH11 are frequently overexpressed in gastric cancer, with high HEYL levels correlating with poor prognosis (Liu et al. 2020).

FOXF1 inhibits CDH11 gene transcription in both human and mouse fibroblasts. Direct repression of CDH11 gene transcription by FOXF1 has been demonstrated in mouse cells. FOXF1-mediated repression of CDH11 transcription, accompanied by FOXF1-mediated activation of CDH2 transcription, is thought to inhibit pulmonary fibrosis by preventing CDH2-CDH11 switch in myofibroblasts. FOXF1-mediated repression of CDH11 gene transcription is associated with the appearance of the repressive H3K27Me3 trimethylation mark on nucleosomes associated with the CDH11 gene promoter (Black et al. 2018).

Based on a mouse study, the transcription factor BHLHE22 (also known as BHLHB5) recruits PRDM8, a histone methyltransferase, to the first intron of the CDH11 gene and directly represses CDH11 transcription. The repression of CDH11 expression by BHLHE22 and PRDM8 is important for the proper axon targeting of corticospinal motor neurons (Ross et al. 2012).

During differentiation of human trophoblasts, TGF-beta-1 (TGFB1) positively regulates CDH11 gene transcription through upregulation of the SNA1 (Snail) transcription factor. While SNAI1 binding sites have been identified in the CDH11 promoter, direct binding has not been reported (Cheng et al. 2018). Positive regulation of CDH11 transcription by SNAI1 has also been reported in synovial fibroblasts (Chen et al. 2015; Cheng et al. 2015).
Literature References
PubMed ID Title Journal Year
32463580 Charactering tumor microenvironment reveals stromal-related transcription factors promote tumor carcinogenesis in gastric cancer

Liu, H, Ni, S, Wang, H, Zhang, Q, Weng, W

Cancer Med 2020
24130169 ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression

Nam, EH, Lee, Y, Zhao, XF, Park, YK, Lee, JW, Kim, S

Carcinogenesis 2014
29642003 FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts

Black, M, Milewski, D, Le, T, Ren, X, Xu, Y, Kalinichenko, VV, Kalin, TV

Cell Rep 2018
16793922 Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells

Lei, H, Juan, AH, Kim, MS, Ruddle, FH

Proc Natl Acad Sci U S A 2006
15699330 The identification of Hoxc8 target genes

Lei, H, Wang, H, Juan, AH, Ruddle, FH

Proc Natl Acad Sci U S A 2005
24810778 HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression

Li, Y, Chao, F, Huang, B, Liu, D, Kim, J, Huang, S

Oncotarget 2014
29269046 TGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation

Cheng, JC, Yi, Y, Chang, HM, Leung, PCK

Cell Signal 2018
29296180 Interleukin enhancer-binding factor 3 and HOXC8 co-activate cadherin 11 transcription to promote breast cancer cells proliferation and migration

Zhang, Y, Yang, C, Zhang, M, Liu, H, Gong, C, Zhang, J, Xu, S, Zou, J, Kai, Y, Li, Y

Oncotarget 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PRDM8:BHLHE22 homodimer:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
BHLHE22 homodimer [nucleoplasm]
PRDM8 [nucleoplasm]
Regulator
FOXF1:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXF1 [nucleoplasm]
Positively by
Regulator
ILF3:HOXC8:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
ILF3:HOXC8 [nucleoplasm]
Regulator
HOXC8:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
HOXC8 [nucleoplasm]
Regulator
SNAI1 [nucleoplasm] (Homo sapiens)
Regulator
HEYL:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
HEYL [nucleoplasm]
Regulator
ZEB2:SP1:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
ZEB2:SP1 [nucleoplasm]
Regulator
ILF3:CDH11 gene [nucleoplasm] (Homo sapiens)
Active Unit
ILF3 [nucleoplasm]
Inferred From
Transcription of Cdh11 gene is repressed by Bhlhe22 and Prdm8 (Mus musculus)
Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-01-05)
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