Transcription of Cdh11 gene is repressed by Bhlhe22 and Prdm8

Stable Identifier
R-MMU-9761140
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcription of Cdh11 gene is repressed by Bhlhe22 and Prdm8
In mouse cells, the transcription factor Bhlhe22 (also known as Bhlhb5) recruits Prdm8, a histone methyltransferase, to the first intron of the Cdh11 gene and directly represses Cdh11 transcription. The repression of Cdh11 expression by Bhlhe22 and Prdm8 is important for the proper axon targeting of corticospinal motor neurons (Ross et al. 2012).
Literature References
PubMed ID Title Journal Year
22284184 Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly

Greenberg, ME, Harrar, D, McInnes, RR, Ross, SE, Lin, Y, Hemberg, M, Mok, SI, Salogiannis, J, Atan, D, Kim, TK, Hu, L, McCord, AE, Jung, C, Cohen, S

Neuron 2012
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Prdm8:Bhlhe22 homodimer:Cdh11 gene [nucleoplasm] (Mus musculus)
Active Unit
Bhlhe22 homodimer [nucleoplasm]
Prdm8 [nucleoplasm]
Orthologous Events
CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-01-10)
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