Reactome | LRR1 [cytosol]

LRR1

Stable Identifier

R-HSA-976019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peptidylprolyl isomerase-like 5, PPIL5, LLR1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Homo sapiens)
        
        CUL2-box protein [cytosol] (Homo sapiens)
        
        LRR1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21074724	CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells	Dev. Cell	2010

External Reference Information

External Reference

UniProt:Q96L50 LRR1

Gene Names

LRR1, PPIL5

Chain

chain:1-414

Reference Genes

BioGPS Gene:122769 LRR1

COSMIC (genes):LRR1 LRR1

CTD Gene:122769 LRR1

dbSNP Gene:122769 LRR1

ENSEMBL:ENSG00000165501 LRR1

HGNC:19742 LRR1

KEGG Gene (Homo sapiens):hsa:122769 LRR1

Monarch:122769 LRR1

NCBI Gene:122769 LRR1

OMIM:609193 LRR1

UCSC:Q96L50 LRR1

Reference Transcript

Other Identifiers

0005360239

11744306_a_at

122769

16783905

235113_at

3534810

3534811

3534812

3534825

3534827

3534833

3534834

3534835

3534836

59759_i_at

59761_r_at

65703

69364

70164_at

7974198

A_14_P103786

A_23_P88362

A_24_P13533

A_33_P3253707

A_33_P3286208

CCDS9686

CCDS9687

ENSG00000165501

ENSP00000298288

ENSP00000315628

ENST00000298288

ENST00000318317

EntrezGene:122769

G3V5H2

GE62192

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0007165

GO:0016567

GO:0043687

HGNC:19742

HPA065703

HPA069364

Hs.179805.0.A1_3p_at

Hs.214186.0.A1_3p_s_at

Hs.451090

ILMN_1715616

ILMN_1778890

ILMN_2293167

ILMN_2411608

LRR1

LRR1-201

LRR1-202

MIM:609193

NM_152329

NM_203467

NP_689542

NP_982292

PF12799

PF13516

PH_hs_0026290

Q6P393

SM00369

TC14000274.hg

TC14001675.hg

uc001wwn.3

uc001wwo.4

UPI0000073FA2

UPI000013E4BC

Participant Of

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

hasMember

CUL2-box protein [cytosol]

Inferred To

LRR1 [cytosol] (Bos taurus)

LRR1 [cytosol] (Caenorhabditis elegans)

LRR1 [cytosol] (Canis familiaris)

LRR1 [cytosol] (Danio rerio)

LRR1 [cytosol] (Drosophila melanogaster)

LRR1 [cytosol] (Gallus gallus)

LRR1 [cytosol] (Mus musculus)

LRR1 [cytosol] (Rattus norvegicus)

LRR1 [cytosol] (Sus scrofa)

LRR1 [cytosol] (Taeniopygia guttata)

LRR1 [cytosol] (Xenopus tropicalis)

Homologues of LRR1 [cytosol] (Canis familiaris)

Homologues of LRR1 [cytosol] (Drosophila melanogaster)

Homologues of LRR1 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_982292.1, NP_689542.2

GeneCards

Q96L50

PRO

Q96L50