Reactome | Lrr1 [cytosol]

Lrr1 [cytosol]

Stable Identifier

R-RNO-976019

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

LRR1, D3ZE86

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Lrr1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZE86

Gene Names

Lrr1

Reference Genes

BioGPS Gene:685860 Lrr1

ENSEMBL:ENSRNOG00000004216

KEGG:rno:685860 Lrr1

Monarch:685860 Lrr1

NCBI Gene:685860 Lrr1

UCSC:D3ZE86 Lrr1

Other Identifiers

10884926

17816230

5630973

5652705

5738988

5783080

6119320

6189893

6316652

6664785

6692751

685860

A_44_P419810

A_64_P123288

GO:0005515

PH_rn_0010838

Participates

as a member of

CUL2-box protein [cytosol] (Rattus norvegicus)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)

Inferred From

LRR1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001102953.1

ENSEMBL

ENSRNOP00000005595, ENSRNOT00000005595, ENSRNOG00000004216

RGD

1589026

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