Ubiquitination of IKBKG by TRAF6

Stable Identifier
R-HSA-9758604
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ubiquitination of IKBKG by TRAF6
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During the phosphorylation of the IKK beta (IKBKB), the regulatory subunit NEMO (IKBKG) undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 acts as a E3 ligase and induces this ubiquitination. Studies of different NF-kappa-B signaling pathways revealed several potential ubiquitination sites on IKBKG (e.g., K285, K277, K309 and K399) (Fuminori et al. 2009).
Literature References
PubMed ID Title Journal Year
17728323 Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti

Sebban-Benin, H, Pescatore, A, Courtois, G, Fusco, F, Ursini, MV, Yamaoka, S, Gautheron, J, Pascuale, V, Moncla, A

Hum Mol Genet 2007
17047224 Regulation and function of IKK and IKK-related kinases

Karin, M, Hacker, H

Sci STKE 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of K63pUb-TRAF6:TAK1 complexes [cytosol]

Physical Entity
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
This event is regulated
Negatively by
Regulator
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Homo sapiens)
Active Unit
USP18 [cytosol]
Orthologous Events
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Drosophila melanogaster)
Ubiquitination of IKBKG by TRAF6 (Mus musculus)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
Authored
Shamovsky, V  (2021-11-09)
Reviewed
de Martin, R  (2022-05-04)
D'Eustachio, P  (2022-01-05)
Created
Shamovsky, V  (2021-11-19)
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