Reactome | UBXN7 binds VCP hexamer:UBF1:NPLOC4

UBXN7 binds VCP hexamer:UBF1:NPLOC4

Stable Identifier

R-HSA-9758088

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UBXN7 interacts with a complex of VCP, UBF1 and NPLOC4 to promote the CRL3- and 26 S proteasome-mediated degradation of factors such as NFE2L2 (Alexandru et al, 2008; Tao et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
18775313	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover Fang, R, Kolawa, NJ, Graumann, J, Smith, GT, Alexandru, G, Deshaies, RJ	Cell	2008
28115426	p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex Rojo de la Vega, M, Chen, H, Zhang, DD, Luo, G, Tao, S, Chapman, E, Wu, T, Tillotson, J, Liu, P	Mol Cell Biol	2017