UBXN7 binds VCP hexamer:UBF1:NPLOC4

Stable Identifier
R-HSA-9758088
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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UBXN7 interacts with a complex of VCP, UBF1 and NPLOC4 to promote the CRL3- and 26 S proteasome-mediated degradation of factors such as NFE2L2 (Alexandru et al, 2008; Tao et al, 2017).

Literature References
PubMed ID Title Journal Year
18775313 UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

Fang, R, Kolawa, NJ, Graumann, J, Smith, GT, Alexandru, G, Deshaies, RJ

Cell 2008
28115426 p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

Rojo de la Vega, M, Chen, H, Zhang, DD, Luo, G, Tao, S, Chapman, E, Wu, T, Tillotson, J, Liu, P

Mol Cell Biol 2017
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