LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene

Stable Identifier
R-HSA-9754191
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene
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In the mouse embryo Tbxt (T, Brachyury) expression in the primitive streak is induced by WNT3 and WNT3A. In vitro studies of human embryonic stem cells (ESCs) show CTNNB1 binding to upstream regions of the TBXT (T, Brachyury) gene after WNT activation (Funa et al. 2015). Expression of the mouse homolog of human TBXT is accompanied by LEF1 binding the TBXT promoter and binding of CTNNB1 (beta-catenin) (inferred from mouse homologs). LEF1 and CTNNB1 are downstream effectors of WNT signaling. TCF7 (TCF1) can also perform the same function as LEF1 (inferred from mouse homologs). During mesendodermal differentiation of human ESCs, TBPL2 (TRF3 binds the TBXT promoter (Liang et al. 2020).
Literature References
PubMed ID Title Journal Year
32448362 TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes

Liang, H, Zhang, P, Bai, HJ, Huang, J, Yang, HT

Stem Cell Res Ther 2020
25921273 β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

Funa, NS, Schachter, KA, Lerdrup, M, Ekberg, J, Hess, K, Dietrich, N, Honoré, C, Hansen, K, Semb, H

Cell Stem Cell 2015
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Inferred From
Lef1 or Tcf7 (tcf1) and Ctnnb1 bind the Tbxt (T, Brachyury) gene (Mus musculus)
Authored
May, B  (2021-09-21)
Reviewed
Tam, PPL  (2022-05-08)
Probst, S  (2022-07-18)
Zissel, L  (2022-07-18)
Salehin, N  (2022-05-08)
Created
May, B  (2021-09-22)
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