Lef1 or Tcf7 (tcf1) and Ctnnb1 bind the Tbxt (T, Brachyury) gene

Stable Identifier
R-MMU-9754284
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Lef1 or Tcf7 (tcf1) and Ctnnb1 bind the Tbxt (T, Brachyury) gene
In the mouse embryo Tbxt (T, Brachyury) expression in the primitive streak is induced by Wnt3 and Wnt3a acting via Lef1, Tcf7 (Tcf1), and beta-catenin (Ctnnb1) (Liu et al. 1999, Yamaguchi et al. 1999). Lef1 binds two sites in the Tbxt (T, Brachyury) promoter and mediates binding of Ctnnb1 to activate Tbxt expression (Yamaguchi et al. 1999, Arnold et al. 2000, Morkel et al. 2003). Tcf7 (Tcf1) can also perform the same function as Lef1 (Yamaguchi et al. 1999).
Literature References
PubMed ID Title Journal Year
14623818 Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Morkel, M, Huelsken, J, Wakamiya, M, Ding, J, van De Wetering, M, Clevers, H, Taketo, MM, Behringer, RR, Shen, MM, Birchmeier, W

Development 2003
10431240 Requirement for Wnt3 in vertebrate axis formation

Liu, P, Wakamiya, M, Shea, MJ, Albrecht, U, Behringer, RR, Bradley, A

Nat Genet 1999
10617567 T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification

Yamaguchi, TP, Takada, S, Yoshikawa, Y, Wu, N, McMahon, AP

Genes Dev 1999
10704849 Brachyury is a target gene of the Wnt/beta-catenin signaling pathway

Arnold, SJ, Stappert, J, Bauer, A, Kispert, A, Herrmann, BG, Kemler, R

Mech Dev 2000
Participants
Input
Output
Orthologous Events
LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (Homo sapiens)
Authored
May, B  (2021-09-22)
Reviewed
Tam, PPL  (2022-05-08)
Probst, S  (2022-07-18)
Zissel, L  (2022-07-18)
Salehin, N  (2022-05-08)
Created
May, B  (2021-09-23)
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