Reactome | RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane

RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane

Stable Identifier

R-HSA-9752980

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, plasma membrane

ReviewStatus

5/5

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RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane

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Some olfactory receptors (ORs), designated underrepresented ORs, are bound to RTP1S (the short isoform of RTP1) and RTP2 and translocate from the endoplasmic reticulum membrane through the Golgi to the plasma membrane (Ikegami et al. 2020, and inferred from mouse homologs). RTP1S and RTP2 increase the efficiency of the translocation by an uncharacterized mechanism (inferred from mouse homologs) though RTP2 decreases translocation of some ORs (inferred from mouse homologs). Some ORs, designated overrepresented ORs, are translocated efficiently without RTP1S or RTP2 (inferred from mouse homologs). REEP1 more weakly enhances translocation (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
31974307	Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors Ikegami, K, de March, CA, Nagai, MH, Ghosh, S, Do, M, Sharma, R, Bruguera, ES, Lu, YE, Fukutani, Y, Vaidehi, N, Yohda, M, Matsunami, H	Proc Natl Acad Sci U S A	2020