Rtp1s:Rtp2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane

Stable Identifier
R-MMU-9753027
Type
Reaction [omitted]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rtp1s:Rtp2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane
Some olfactory receptors (ORs), designated underrepresented ORs, are bound to RTP1S (the short isoform of RTP1) and RTP2 and translocate from the endoplasmic reticulum membrane through the Golgi to the plasma membrane (Saito et al. 2004, Sharma et al. 2017, Yu et al. 2017, Fukutani et al. 2019, Ikegami et al. 2020). RTP1S and RTP2 increase the efficiency of the translocation by an uncharacterized mechanism (Saito et al. 2004, Sharma et al. 2017, Yu et al. 2017, Fukutani et al. 2019, Ikegami et al. 2020) though RTP2 decreases translocation of some ORs (Yu et al. 2017). Some ORs, designated overrepresented ORs, are translocated efficiently without RTP1S or RTP2 (Sharma et al. 2017, Ikegami et al. 2020). REEP1 more weakly enhances translocation (Saito et al. 2004).
Literature References
PubMed ID Title Journal Year
15550249 RTP family members induce functional expression of mammalian odorant receptors

Saito, H, Kubota, M, Roberts, RW, Chi, Q, Matsunami, H

Cell 2004
28262096 Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice

Sharma, R, Ishimaru, Y, Davison, I, Ikegami, K, Chien, MS, You, H, Chi, Q, Kubota, M, Yohda, M, Ehlers, M, Matsunami, H

Elife 2017
31395660 The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking

Fukutani, Y, Tamaki, R, Inoue, R, Koshizawa, T, Sakashita, S, Ikegami, K, Ohsawa, I, Matsunami, H, Yohda, M

J Biol Chem 2019
31974307 Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

Ikegami, K, de March, CA, Nagai, MH, Ghosh, S, Do, M, Sharma, R, Bruguera, ES, Lu, YE, Fukutani, Y, Vaidehi, N, Yohda, M, Matsunami, H

Proc Natl Acad Sci U S A 2020
28586385 Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors

Yu, T, Su, X, Pan, Y, Zhuang, H

PLoS One 2017
Participants
Input
Output
This event is regulated
Positively by
Regulator
Reep1 [endoplasmic reticulum membrane] (Mus musculus)
Orthologous Events
RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane (Homo sapiens)
Authored
May, B  (2021-09-06)
Reviewed
Raimondi, F  (2021-11-10)
Created
May, B  (2021-09-06)
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