Gain-of-function MRAS complexes activate RAF signaling

Stable Identifier
R-HSA-9726842
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Gain-of-function MRAS complexes activate RAF signaling
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This pathway describes the effect of activating mutations of MRAS-complex components on RAF activation (reivewed in Simanshu et al, 2017).
Literature References
PubMed ID Title Journal Year
28666118 RAS Proteins and Their Regulators in Human Disease

McCormick, F, Nissley, DV, Simanshu, DK

Cell 2017
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
esophageal carcinoma DOID:1107 carcinoma OF ESOPHAGUS, carcinoma of oesophagus, cancer of esophagus, cancer of oesophagus, carcinoma of esophagus (disorder), carcinoma of esophagus (disorder)
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
Cross References
BioModels Database
Authored
Rothfels, K  (2019-10-25)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2021-04-12)
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