NPM1-ALK translocates to the nucleus

Stable Identifier
R-HSA-9725009
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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NPM1-ALK translocates to the nucleus
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Unique so far among ALK fusion proteins, NPM1-ALK is partially nuclear in localization. Endogenous full length NPM is a nuclear-cytoplasmic shuttling protein that contains a nuclear localization signal; although this domain is not conserved in the NPM-ALK fusion, nuclear localization of NPM-ALK is believed to be facilitated by oligomerization with full-length NPM, which exists in dimeric and pentameric states (Kim et al, 2015; reviewed in Box et al ,2006; Okuwaki, 2007; Ducray et al, 2019). Partial nuclear localization of NPM-ALK allows it to perform roles in transcriptional and epigenetic regulation (reviewed in Ducray et al, 2019).
Literature References
PubMed ID Title Journal Year
31366041 The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis

Ducray, SP, Natarajan, K, Garland, GD, Turner, SD, Egger, G

Cancers (Basel) 2019
18024471 The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein

Okuwaki, M

J Biochem 2008
27553022 Nucleophosmin: from structure and function to disease development

Box, JK, Paquet, N, Adams, MN, Boucher, D, Bolderson, E, O'Byrne, KJ, Richard, DJ

BMC Mol Biol 2016
25818168 GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer

Kim, JY, Cho, YE, An, YM, Kim, SH, Lee, YG, Park, JH, Lee, S

J Cell Mol Med 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NPM dimer [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2021-03-26)
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