Unique so far among ALK fusion proteins, NPM1-ALK is partially nuclear in localization. Endogenous full length NPM is a nuclear-cytoplasmic shuttling protein that contains a nuclear localization signal; although this domain is not conserved in the NPM-ALK fusion, nuclear localization of NPM-ALK is believed to be facilitated by oligomerization with full-length NPM, which exists in dimeric and pentameric states (Kim et al, 2015; reviewed in Box et al ,2006; Okuwaki, 2007; Ducray et al, 2019). Partial nuclear localization of NPM-ALK allows it to perform roles in transcriptional and epigenetic regulation (reviewed in Ducray et al, 2019).
Ducray, SP, Turner, SD, Garland, GD, Natarajan, K, Egger, G
Okuwaki, M
Paquet, N, O'Byrne, KJ, Bolderson, E, Boucher, D, Adams, MN, Box, JK, Richard, DJ
Kim, SH, An, YM, Park, JH, Cho, YE, Lee, S, Kim, JY, Lee, YG
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