ALK fusion proteins bind PLCG1

Stable Identifier
R-HSA-9710917
Type
Reaction
Species
Homo sapiens
Compartment
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Based on studies with the oncogenic NPM-ALK fusion, oncogenic ALK fusions are believed to signal through the PLC gamma signaling pathway. PLCG1 binds to phosphorylated tyrosine 1604 on the activated receptor. PLCG1 signaling contributes to mitogenesis and cellular proliferation downstream of ALK signaling (Bai et al, 1998; Hernandez et al, 2002; reviewed in Chiarle et al, 2008; Hallberg and Palmer, 2013; Roskoski, 2013; Ducray et al, 2019).

Literature References
PubMed ID Title Journal Year
11943732 Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity

Bellosillo, B, Morris, SW, Pulford, K, Rosenwald, A, Beà, S, Mason, D, Hernández, L, Pinyol, M, Ott, G, Falini, B, Santos, E, Fernández, A, Carbone, A, Campo, E

Am. J. Pathol. 2002
31366041 The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis

Ducray, SP, Turner, SD, Garland, GD, Natarajan, K, Egger, G

Cancers (Basel) 2019
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

Dieter, P, Morris, SW, Bai, RY, Duyster, J, Peschel, C

Mol. Cell. Biol. 1998
23201355 Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

Roskoski, R

Pharmacol. Res. 2013
24060861 Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

Palmer, RH, Hallberg, B

Nat. Rev. Cancer 2013
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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