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PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane]
Stable Identifier
R-HSA-9710910
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusion proteins bind PLCG1 (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
ALK fusions phosphorylate PLCG1 (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
Participants
components
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol]
(Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
PLCG1 [plasma membrane]
(Homo sapiens)
Participates
as an output of
ALK fusion proteins bind PLCG1 (Homo sapiens)
as an input of
ALK fusions phosphorylate PLCG1 (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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