linafinib-resistant FLT3 mutants don't bind linifanib

Stable Identifier
R-HSA-9702997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following FLT3 mutants are resistant to linifanib-mediated inhibition:

FLT3 D835A (Nguyen et al, 2017)
FLT3 D835Y (Nguyen et al, 2017)

Literature References
PubMed ID Title Journal Year
21471285 The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway

Hernandez-Davies, JE, Zape, JP, Landaw, EM, Tan, X, Presnell, A, Griffith, D, Heinrich, MC, Glaser, KB, Sakamoto, KM

Mol. Cancer Ther. 2011
28077790 FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B, Williams, AB, Young, DJ, Ma, H, Li, L, Levis, M, Brown, P, Small, D

Oncotarget 2017
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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