tandutinib-resistant FLT3 mutants don't bind tandutinib

Stable Identifier
R-HSA-9702638
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following FLT3 mutants are resistant to inhibition by tandutinib:

FLT3 D835V (Clark et al, 2004)
FLT3 D835Y (Clark et al, 2004)

Literature References
PubMed ID Title Journal Year
15256420 Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Clark, JJ, Cools, J, Curley, DP, Yu, JC, Lokker, NA, Giese, NA, Gilliland, DG

Blood 2004
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
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Created
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