tandutinib-resistant FLT3 mutants don't bind tandutinib

Stable Identifier
R-HSA-9702638
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The following FLT3 mutants are resistant to inhibition by tandutinib:

FLT3 D835V (Clark et al, 2004)
FLT3 D835Y (Clark et al, 2004)

Literature References
PubMed ID Title Journal Year
15256420 Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Gilliland, DG, Lokker, NA, Curley, DP, Clark, JJ, Giese, NA, Yu, JC, Cools, J

Blood 2004
Participants
Participates
Normal reaction
Functional status

Loss of function of tandutinib-resistant FLT3 mutants [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
Cite Us!