tandutinib-resistant FLT3 mutants don't bind tandutinib

Stable Identifier
R-HSA-9702638
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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tandutinib-resistant FLT3 mutants don't bind tandutinib
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The following FLT3 mutants are resistant to inhibition by tandutinib:

FLT3 D835V (Clark et al, 2004)
FLT3 D835Y (Clark et al, 2004)

Literature References
PubMed ID Title Journal Year
15256420 Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Gilliland, DG, Lokker, NA, Curley, DP, Clark, JJ, Giese, NA, Yu, JC, Cools, J

Blood 2004
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as an event of
Normal reaction
FLT3 binds type II TKI (Homo sapiens)
Functional status

Loss of function of tandutinib-resistant FLT3 mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-01)
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