FLT3 binds type II TKI

Stable Identifier
R-HSA-9695831
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FLT3 can be bound and inhibited by class II tyrosine kinase inhibitors including sunitinib, sorafenib and others. Type II inhibitors bind to the inactive conformation of the kinase and prevent its activation (reviewed in Larrosa-Garcia and Baer, 2017; Lim et al, 2017; Klug et al, 2018).

Literature References
PubMed ID Title Journal Year
29964125 Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases

Klug, LR, Kent, JD, Heinrich, MC

Pharmacol. Ther. 2018
28576946 FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions

Larrosa-Garcia, M, Baer, MR

Mol. Cancer Ther. 2017
28851395 Molecular targeting in acute myeloid leukemia

Lim, SH, Dubielecka, PM, Raghunathan, VM

J Transl Med 2017
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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