semaxanib-resistant FLT3 mutants don't bind semaxanib<br>

Stable Identifier
R-HSA-9702578
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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semaxanib-resistant FLT3 mutants don't bind semaxanib<br>
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The following FLT3 mutants are resistant to inhibition by semaxanib:

FLT3 D835N (partial: Bagrintseva et al, 2005)
FLT3 D835Y (partial: Bagrintseva et al, 2005)
Literature References
PubMed ID Title Journal Year
15626738 FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)

Bagrintseva, K, Geisenhof, S, Kern, R, Eichenlaub, S, Reindl, C, Ellwart, JW, Hiddemann, W, Spiekermann, K

Blood 2005
Participants
Input
Participates
as an event of
Normal reaction
FLT3 binds type I TKI (Homo sapiens)
Functional status

Loss of function of semaxanib-resistant FLT3 mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-01)
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