semaxanib-resistant FLT3 mutants don't bind semaxanib<br>

Stable Identifier
R-HSA-9702578
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following FLT3 mutants are resistant to inhibition by semaxanib:

FLT3 D835N (partial: Bagrintseva et al, 2005)
FLT3 D835Y (partial: Bagrintseva et al, 2005)

Literature References
PubMed ID Title Journal Year
15626738 FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)

Bagrintseva, K, Geisenhof, S, Kern, R, Eichenlaub, S, Reindl, C, Ellwart, JW, Hiddemann, W, Spiekermann, K

Blood 2005
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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