Active ALK binds JAK3

Stable Identifier
R-HSA-9701485
Type
Reaction
Species
Homo sapiens
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Based on studies with NPM-ALK fusion proteins, ALK appears to signal through JAK3 in a manner that depends on JAK3-ALK binding (Zamo et al, 2002; Amin et al, 2003; Lai et al, 2005). When co-expressed in HEK293 cells, JAK3 binds to residues corresponding to 1058 to 1077 of the full length ALK receptor (Zamo et al, 2002). Although JAK3 often signals through recruitment and phosphorylation of STAT3, it is unclear whether STAT3 activation downstream of ALK depends on JAK3 (Zamo et al, 2002; Amin et al, 2003; Marzec et al, 2005; Han et al, 2006 a,b; Lai et al, 2005; Shi et al, 2006; reviewed in Palmer et al, 2009).

Literature References
PubMed ID Title Journal Year
12934099 Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma

Ma, Y, Amin, HM, Rassidakis, GZ, Feretzaki, M, Leventaki, V, Medeiros, LJ, Lai, R, McDonnell, TJ, O'Connor, SL, Das, P

Oncogene 2003
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
11850821 Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

Chiarle, R, Piva, R, Inghirami, G, Levy, DE, Howes, J, Fan, Y, Chilosi, M, Zamo, A

Oncogene 2002
16170336 Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3

Wasik, MA, Wlodarski, P, Zhang, Q, Marzec, M, Odum, N, Kasprzycka, M, Ptasznik, A

Lab. Invest. 2005
16939498 JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells

Frantz, C, Amin, HM, Franko, B, Lai, R, Shi, X

Br. J. Haematol. 2006
16153455 Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma

Amin, HM, Atwell, C, Rassidakis, GZ, Medeiros, LJ, Lin, Q, Lai, R

Hum. Pathol. 2005
16825495 Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma

Frantz, C, Amin, HM, Franko, B, Han, Y, Lai, R, Shi, X

Blood 2006
16871283 Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma

Amin, HM, Franko, B, Frantz, C, Han, Y, Lai, R, Lin, Q, Lee, J

Leukemia 2006
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