Reactome | Active ALK binds JAK3

Active ALK binds JAK3

Stable Identifier

R-HSA-9701485

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Based on studies with NPM-ALK fusion proteins, ALK appears to signal through JAK3 in a manner that depends on JAK3-ALK binding (Zamo et al, 2002; Amin et al, 2003; Lai et al, 2005). When co-expressed in HEK293 cells, JAK3 binds to residues corresponding to 1058 to 1077 of the full length ALK receptor (Zamo et al, 2002). Although JAK3 often signals through recruitment and phosphorylation of STAT3, it is unclear whether STAT3 activation downstream of ALK depends on JAK3 (Zamo et al, 2002; Amin et al, 2003; Marzec et al, 2005; Han et al, 2006 a,b; Lai et al, 2005; Shi et al, 2006; reviewed in Turner and Alexander, 2006; Palmer et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
12934099	Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma Amin, HM, Medeiros, LJ, Ma, Y, Feretzaki, M, Das, P, Leventaki, V, Rassidakis, GZ, O'Connor, SL, McDonnell, TJ, Lai, R	Oncogene	2003
19459784	Anaplastic lymphoma kinase: signalling in development and disease Palmer, RH, Vernersson, E, Grabbe, C, Hallberg, B	Biochem. J.	2009
11850821	Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death Zamo, A, Chiarle, R, Piva, R, Howes, J, Fan, Y, Chilosi, M, Levy, DE, Inghirami, G	Oncogene	2002
16482213	Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells Turner, SD, Alexander, DR	Leukemia	2006
16170336	Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3 Marzec, M, Kasprzycka, M, Ptasznik, A, Wlodarski, P, Zhang, Q, Odum, N, Wasik, MA	Lab. Invest.	2005
16939498	JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells Shi, X, Franko, B, Frantz, C, Amin, HM, Lai, R	Br. J. Haematol.	2006
16153455	Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma Lai, R, Rassidakis, GZ, Lin, Q, Atwell, C, Medeiros, LJ, Amin, HM	Hum. Pathol.	2005
16825495	Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma Han, Y, Amin, HM, Franko, B, Frantz, C, Shi, X, Lai, R	Blood	2006
16871283	Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma Han, Y, Amin, HM, Frantz, C, Franko, B, Lee, J, Lin, Q, Lai, R	Leukemia	2006