Active ALK binds PLCG1

Stable Identifier
R-HSA-9700149
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Active ALK binds PLCG1
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Based on studies with the oncogenic NPM-ALK fusion, ALK is predicted to signal through the PLC gamma signaling pathway. PLCG1 binds to phosphorylated tyrosine 1604 on the activated receptor. PLCG1 signaling contributes to mitogenesis and cellular proliferation downstream of ALK signaling (Bai et al, 1998; reviewed in Turner and Alexander, 2006; Chiarle et al, 2008).
Literature References
PubMed ID Title Journal Year
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Voena, C, Ambrogio, C, Piva, R, Inghirami, G

Nat. Rev. Cancer 2008
16482213 Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells

Turner, SD, Alexander, DR

Leukemia 2006
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

Bai, RY, Dieter, P, Peschel, C, Morris, SW, Duyster, J

Mol. Cell. Biol. 1998
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Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Turner, S  (2023-11-08)
Created
Rothfels, K  (2020-09-14)
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