3CLp dimer:3CLp inhibitors [cytosol]

Stable Identifier
R-COV-9694375
Type
Complex
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
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Literature References
PubMed ID Title Journal Year
32272481 Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Duan, Y, Zhang, L, Jin, Z, Jiang, R, Shi, Z, Deng, Y, Qin, C, Zhang, B, Yang, H, Wang, L, Xu, Y, Liu, H, You, T, Du, X, Peng, C, Liu, M, Liu, X, Xu, W, Yang, X, Yang, X, Liu, F, Li, X, Rao, Z, Xiao, G, Zhao, Y, Jiang, H, Liu, X, Bai, F, Yu, J, Yang, K, Guddat, LW

Nature 2020
32541865 Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Sacco, MD, Marty, MT, Chen, Y, Townsend, JA, Wang, J, Zhang, X, Hu, Y, Hurst, B, Ma, C, Szeto, T, Tarbet, B

Cell Res 2020
34029993 Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

Deval, J, Vandyck, K

Curr Opin Virol 2021
Participants
components
Participates
as an output of
This entity regulates
Negatively
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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