nsp4 is glycosylated

Stable Identifier
R-HSA-9694611
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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nsp4 is glycosylated
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Part of nsp4 protein becomes N-glycosylated and gets recruited to the replication complexes in infected cells (Oostra et al, 2007).
Literature References
PubMed ID Title Journal Year
17855519 Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication

Oostra, M, te Lintelo, EG, Deijs, M, Verheije, MH, Rottier, PJ, de Haan, CA

J. Virol. 2007
Participants
Input
Output
Participates
as an event of
Inferred From
nsp4 is glycosylated (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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