pp1a forms a dimer

Stable Identifier
R-HSA-9694567
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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pp1a forms a dimer
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

In the host cell cytosol the pp1a polyprotein spontaneously dimerizes. This temporary dimer has weak protease activity (Chen et al, 2010)
Literature References
PubMed ID Title Journal Year
27799534 SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

Wang, H, Nishii, W, Kim, YT, Shirouzu, M, Takemoto, C, Terada, T, Muramatsu, T, Yokoyama, S

Proc. Natl. Acad. Sci. U.S.A. 2016
21203998 Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode

Hilgenfeld, R, Chen, S, Shen, C, Higenfeld, R, Jonas, F

Protein Cell 2010
Participants
Input
Output
Participates
as an event of
Inferred From
pp1a forms a dimer (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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