pp1a forms a dimer

Stable Identifier
R-HSA-9684350
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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In the host cell cytosol the pp1a polyprotein spontaneously dimerizes. This temporary dimer has weak protease activity (Chen et al, 2010).

Literature References
PubMed ID Title Journal Year
21203998 Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode

Chen, S, Jonas, F, Shen, C, Hilgenfeld, R, Higenfeld, R

Protein Cell 2010
27799534 SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

Muramatsu, T, Takemoto, C, Kim, YT, Wang, H, Nishii, W, Terada, T, Shirouzu, M, Yokoyama, S

Proc. Natl. Acad. Sci. U.S.A. 2016
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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