pp1a forms a dimer

Stable Identifier
R-HSA-9684350
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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In the host cell cytosol the pp1a polyprotein spontaneously dimerizes. This temporary dimer has weak protease activity (Chen et al, 2010).

Literature References
PubMed ID Title Journal Year
27799534 SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

Wang, H, Nishii, W, Kim, YT, Shirouzu, M, Takemoto, C, Terada, T, Muramatsu, T, Yokoyama, S

Proc. Natl. Acad. Sci. U.S.A. 2016
21203998 Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode

Hilgenfeld, R, Chen, S, Shen, C, Higenfeld, R, Jonas, F

Protein Cell 2010
Participants
Participates
Orthologous Events
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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