Endocytois of SARS-CoV-1 Virion

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Human SARS coronavirus
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SARS-CoV-1 virions attached to the host cell surface via a complex involving viral spike (S) protein and host angiotensin-converting enzyme 2 (ACE2) undergo endocytosis. Studies with pseudoviruses have established that S protein is necessary and sufficient for mediating viral attachment and entry. Inhibition of this SARS-CoV-1 S protein-mediated transduction by two different classes of lysosomotropic agents in multiple cell lines strongly suggests that acidification of endosomes is needed for viral entry (Hofmann et al. 2004; Simmons et al. 2004; Yang et al. 2004). The roles of S protein in viral binding to the host cell membrane and fusion of viral and host cell membranes and thus the central role of S protein in determining the host range and tissue tropisms of the virus are reviewed by Belouzard et al. (2012).
Literature References
PubMed ID Title Journal Year
15163706 S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients

Niedrig, M, Krumbiegel, M, Pöhlmann, S, Gramberg, T, Kuate, S, Marzi, A, Uberla, K, Geier, M, Hattermann, K, Hofmann, H

J. Virol. 2004
15140961 pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN

Leung, K, Kong, WP, Huang, Y, Subbarao, K, Nabel, GJ, Yang, ZY, Ganesh, L, Schwartz, O

J. Virol. 2004
22816037 Mechanisms of coronavirus cell entry mediated by the viral spike protein

Licitra, BN, Belouzard, S, Millet, JK, Whittaker, GR

Viruses 2012
15010527 Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry

Bates, P, Piefer, AJ, Reeves, JD, Simmons, G, Amberg, SM, Rennekamp, AJ

Proc. Natl. Acad. Sci. U.S.A. 2004
Orthologous Events
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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