Endocytois of SARS-CoV-1 Virion

Stable Identifier
R-HSA-9686711
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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General
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SARS-CoV-1 virions attached to the host cell surface via a complex involving viral spike (S) protein and host angiotensin-converting enzyme 2 (ACE2) undergo endocytosis. Studies with pseudoviruses have established that S protein is necessary and sufficient for mediating viral attachment and entry. Inhibition of this SARS-CoV-1 S protein-mediated transduction by two different classes of lysosomotropic agents in multiple cell lines strongly suggests that acidification of endosomes is needed for viral entry (Hofmann et al. 2004; Simmons et al. 2004; Yang et al. 2004). The roles of S protein in viral binding to the host cell membrane and fusion of viral and host cell membranes and thus the central role of S protein in determining the host range and tissue tropisms of the virus are reviewed by Belouzard et al. (2012).

Literature References
PubMed ID Title Journal Year
15140961 pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN

Yang, ZY, Huang, Y, Ganesh, L, Leung, K, Kong, WP, Schwartz, O, Subbarao, K, Nabel, GJ

J. Virol. 2004
15163706 S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients

Hofmann, H, Hattermann, K, Marzi, A, Gramberg, T, Geier, M, Krumbiegel, M, Kuate, S, Uberla, K, Niedrig, M, Pöhlmann, S

J. Virol. 2004
22816037 Mechanisms of coronavirus cell entry mediated by the viral spike protein

Belouzard, S, Millet, JK, Licitra, BN, Whittaker, GR

Viruses 2012
15010527 Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry

Simmons, G, Reeves, JD, Rennekamp, AJ, Amberg, SM, Piefer, AJ, Bates, P

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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