Attachment and Entry

Stable Identifier
R-HSA-9678110
Type
Pathway
Species
Homo sapiens
Related Species
Human SARS coronavirus
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General
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Coronavirus replication is initiated by the binding of S protein to the cell surface receptor(s). The S protein is composed of two functional domains, S1 (bulb) which mediates receptor binding and S2 (stalk) which mediates membrane fusion. Specific interaction between S1 and the cognate receptor triggers a drastic conformational change in S2, leading to fusion between the virus envelope and the cellular membrane and release of the viral nucleocapsid into the host cell cytosol. Receptor binding is the major determinant of the host range and tissue tropism for a coronavirus. Some human coronaviruses (HCoVs ) have adopted cell surface enzymes as receptors, angiotensin converting enzyme 2 (ACE2) for SARS CoV-1 and HCoV NL63. The receptor-bound S protein is activated by cleavage into S1 and S2, mediated by one of two of two host proteases, the endosomal cysteine protease cathepsin L and another trypsin like serine protease. Type II transmembrane serine proteases TMPRSS2 and TMPRSS11D have also been implicated in the activation of S protein of SARS CoV-1. Host factors may play additional roles in viral entry (not annotated here). Valosin containing protein (VCP) contributes by a poorly understood mechanism to the release of coronavirus from early endosomes. Host factors may also restrict the attachment and entry of HCoV. Some interferon inducible transmembrane proteins (IFITMs) exhibited broad spectrum antiviral functions against various RNA viruses including SARS CoV-1 while others may facilitate HCoV entry into host cells (Fung & Liu 2019).

Literature References
PubMed ID Title Journal Year
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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