Fusion and Release of SARS-CoV-1 Nucleocapsid

Stable Identifier
R-HSA-9686699
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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The SARS-CoV-1 nucleocapsid is released from the host cell endosome into the cytosol. Molecular details of this step are not well worked out. Studies of the infection of the human cultured cells with HCoV-229E coronavirus established a requirement for VCP (transitional endoplasmic reticulum ATPase) protein function for release to occur (Wong et al. 2015). A similar requirement for VCP involvement in SARS-CoV-1 nucleocapsid release is inferred here.

Literature References
PubMed ID Title Journal Year
26311884 Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes

Wong, HH, Kumar, P, Tay, FP, Moreau, D, Liu, DX, Bard, F

J. Virol. 2015
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Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
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