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Fusion and Release of SARS-CoV-1 Nucleocapsid
Stable Identifier
R-HSA-9686699
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endocytic vesicle membrane
ReviewStatus
5/5
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SARS-CoV-1 Infection (Homo sapiens)
Attachment and Entry (Homo sapiens)
Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)
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The SARS-CoV-1 nucleocapsid is released from the host cell endosome into the cytosol. Molecular details of this step are not well worked out. Studies of the infection of the human cultured cells with HCoV-229E coronavirus established a requirement for VCP (transitional endoplasmic reticulum ATPase) protein function for release to occur (Wong et al. 2015). A similar requirement for VCP involvement in SARS-CoV-1 nucleocapsid release is inferred here.
Literature References
PubMed ID
Title
Journal
Year
26311884
Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes
Liu, DX
,
Moreau, D
,
Wong, HH
,
Tay, FP
,
Bard, F
,
Kumar, P
J. Virol.
2015
Participants
Input
S1:S2:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen]
(Human SARS coronavirus)
Output
encapsidated SARS coronavirus genomic RNA (plus strand) [cytosol]
(Human SARS coronavirus)
S1:S2:M:E: 7a:O-glycosyl 3a tetramer [endocytic vesicle membrane]
(Human SARS coronavirus)
Participates
as an event of
Attachment and Entry (Homo sapiens)
This event is regulated
Positively by
Regulator
VCP [cytosol]
(Homo sapiens)
Orthologous Events
Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Authored
Gillespie, ME (2020-05-05)
Reviewed
Acencio, ML (2020-05-27)
Mazein, A (2020-05-27)
Created
Gillespie, ME (2020-05-05)
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