nsp16 binds VHL

Stable Identifier
R-HSA-9683455
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
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nsp16 binds VHL
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Human von Hippel Lindau (VHL) protein, a tumor suppressor that acts as a component of an E3 ubiquitin ligase complex, interacts with the non-structural protein 16 (nsp16) of the human SARS coronavirus 1 (SARS-CoV-1) and the mouse hepatitis virus, also a coronavirus. VHL negatively regulates SARS-CoV-1 replication, but the exact mechanism is not known (Yu et al. 2015).

Literature References
PubMed ID Title Journal Year
25732088 VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability

Hou, P, Guo, D, Chen, Y, Chen, S, Wang, M, Yu, X

Biochem. Biophys. Res. Commun. 2015
Participants
Input
Output
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as an event of
Orthologous Events
nsp16 binds VHL (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-16)
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