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pp1ab-nsp16 [cytosol]
Stable Identifier
R-COV-9678289
Type
Protein [EntityWithAccessionedSequence]
Species
Human SARS coronavirus
Compartment
cytosol
Synonyms
2'-O-methyltransferase, rep (6776 – 7073)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-1 genome (Homo sapiens)
RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)
SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement (Homo sapiens)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)
SARS coronavirus gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
m7GpppA-capped SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
m7GpppA-capped SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp16 binds VHL (Homo sapiens)
nsp16:VHL [cytosol] (Homo sapiens)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp8 generates RNA primers (Homo sapiens)
SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
Transcription of SARS-CoV-1 sgRNAs (Homo sapiens)
Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching (Homo sapiens)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)
SARS-CoV-1 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
SARS-CoV-1 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
m7GpppA-SARS-CoV-1 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
m7GpppA-SARS-CoV-1 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 dsRNA intermediates bind DDX58 (Homo sapiens)
SARS-CoV-1 dsRNA intermediates:DDX58:ATP [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)
SARS-CoV-1 dsRNA intermediates:IFIH1 [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-1 dsRNA with poly(U)-contaiining (-) strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 dsRNA with poly(U)-contaiining (-) strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp15 cleaves viral poly(U)-RNA (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS coronavirus gRNA with secondary structure:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS coronavirus gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 dsRNA with poly(U)-contaiining (-) strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) (Homo sapiens)
nsp16 binds nsp10 (Homo sapiens)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)
RTC [double membrane vesicle viral factory outer membrane] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
Maturation of replicase proteins (Homo sapiens)
3CLp cleaves pp1ab (Homo sapiens)
pp1ab-nsp16 [cytosol] (Human SARS coronavirus)
External Reference Information
External Reference
UniProt:P0C6X7 rep
Gene Names
rep, 1a-1b
Chain
chain:1-180, chain:181-818, chain:819-2740, chain:2741-3240, chain:3241-3546, chain:3547-3836, chain:3837-3919, chain:3920-4117, chain:4118-4230, chain:4231-4369, chain:4370-5301, chain:5302-5902, chain:5903-6429, chain:6430-6775, chain:6776-7073
Participates
as an input of
nsp16 binds nsp10 (Homo sapiens)
nsp16 binds VHL (Homo sapiens)
as a component of
nsp16:VHL [cytosol] (Homo sapiens)
nsp16:nsp10 [cytosol] (Human SARS coronavirus)
as an output of
3CLp cleaves pp1ab (Homo sapiens)
Other forms of this molecule
N-glycan pp1ab-nsp4 [endoplasmic reticulum membrane]
N-glycan pp1ab-nsp3 [endoplasmic reticulum membrane]
pp1ab-nsp4 [cytosol]
pp1ab-nsp3 [cytosol]
N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane]
pp1ab-nsp9 [cytosol]
pp1ab-nsp6 [endoplasmic reticulum membrane]
pp1ab-nsp5 [cytosol]
pp1ab-nsp2 [cytosol]
pp1ab-nsp3-4 [cytosol]
pp1ab-nsp1 [cytosol]
pp1ab-nsp1-4 [cytosol]
pp1ab [cytosol]
pp1ab-nsp6 [double membrane vesicle viral factory outer membrane]
pp1ab-nsp4 [double membrane vesicle viral factory outer membrane]
pp1ab-nsp3 [double membrane vesicle viral factory outer membrane]
pp1ab-nsp13 [cytosol]
pp1ab-nsp12 [cytosol]
pp1ab-nsp7 [cytosol]
pp1ab-nsp8 [cytosol]
pp1ab-nsp14 [cytosol]
pp1ab-nsp10 [cytosol]
pp1ab-nsp15 [cytosol]
Inferred To
pp1ab-nsp16 [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0C6X7 rep
20
N-glycan pp1ab-nsp4 [endoplasmic reticulum membrane]
(R-COV-9684860)
N-glycan pp1ab-nsp3 [endoplasmic reticulum membrane]
(R-COV-9682204)
pp1ab-nsp4 [cytosol]
(R-COV-9684868)
pp1ab-nsp3 [cytosol]
(R-COV-9684867)
N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane]
(R-COV-9684874)
pp1ab-nsp9 [cytosol]
(R-COV-9682232)
pp1ab-nsp6 [endoplasmic reticulum membrane]
(R-COV-9682233)
pp1ab-nsp5 [cytosol]
(R-COV-9682196)
pp1ab-nsp2 [cytosol]
(R-COV-9682221)
pp1ab-nsp3-4 [cytosol]
(R-COV-9684864)
pp1ab-nsp1 [cytosol]
(R-COV-9682211)
pp1ab-nsp1-4 [cytosol]
(R-COV-9684861)
pp1ab [cytosol]
(R-COV-9684355)
pp1ab-nsp6 [double membrane vesicle viral factory outer membrane]
(R-COV-9685986)
pp1ab-nsp4 [double membrane vesicle viral factory outer membrane]
(R-COV-9686029)
pp1ab-nsp3 [double membrane vesicle viral factory outer membrane]
(R-COV-9685989)
pp1ab-nsp16 [cytosol]
(R-COV-9678289)
pp1ab-nsp13 [cytosol]
(R-COV-9678281)
pp1ab-nsp12 [cytosol]
(R-COV-9678280)
pp1ab-nsp7 [cytosol]
(R-COV-9682244)
0.676
3
UniProt:O75348 ATP6V1G1
1
ATP6V1G1 [cytosol]
(R-HSA-912578)
0.656
5
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