NBR1 translocates from cytosol to perixosomal membrane

Stable Identifier
R-HSA-9664871
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, peroxisomal membrane
ReviewStatus
5/5
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NBR1 translocates from cytosol to perixosomal membrane
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Pexophagy is known to be regulated by molecular oxygen stress as a means of adaptive response. Low oxygen tension stabilizes Endothelial PAS domain containing protein 1 (EPAS1), which positively regulates the translocation of Next to BRCA1 gene 1 protein (NBR1) from the cytosol to the peroxisomal membrane. NBR1 binds peroxisomes through its JUBA domain (Walter KM et al. 2014).
Literature References
PubMed ID Title Journal Year
25440060 Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy

Kovacs, WJ, Walter, KM, Trötzmüller, M, Krek, W, Moser, AB, Lucas, MS, Köfeler, HC, Moch, H, Faust, PL, Schönenberger, MJ, Elsässer, HP, Gerber, PA, Horn, M, Schwarz, T

Cell Metab. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
EPAS1 [cytosol] (Homo sapiens)
Inferred From
Nbr1 translocates from cytosol to perixosomal membrane (Mus musculus)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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