NBR1 translocates from cytosol to perixosomal membrane

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R-HSA-9664871
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Reaction [uncertain]
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Homo sapiens
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Pexophagy is known to be regulated by molecular oxygen stress as a means of adaptive response. Low oxygen tension stabilizes Endothelial PAS domain containing protein 1 (EPAS1), which positively regulates the translocation of Next to BRCA1 gene 1 protein (NBR1) from the cytosol to the peroxisomal membrane. NBR1 binds peroxisomes through its JUBA domain (Walter KM et al. 2014).

Literature References
PubMed ID Title Journal Year
25440060 Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy

Walter, KM, Schönenberger, MJ, Trötzmüller, M, Horn, M, Elsässer, HP, Moser, AB, Lucas, MS, Schwarz, T, Gerber, PA, Faust, PL, Moch, H, Köfeler, HC, Krek, W, Kovacs, WJ

Cell Metab. 2014
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