Nbr1 translocates from cytosol to perixosomal membrane

Stable Identifier
R-MMU-9666410
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Nbr1 translocates from cytosol to perixosomal membrane

Molecular oxygen regulates the translocation of the autophagy receptor Next to BRCA1 gene 1 protein (Nbr1) from the cytosol to the peroxisomal membrane. Low oxygen stimulates Endothelial PAS domain containing protein 1 (Epas1), which positively regulates the translocation of Nbr1 (Walter KM et al. 2014).

Literature References
PubMed ID Title Journal Year
25440060 Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy

Walter, KM, Schönenberger, MJ, Trötzmüller, M, Horn, M, Elsässer, HP, Moser, AB, Lucas, MS, Schwarz, T, Gerber, PA, Faust, PL, Moch, H, Köfeler, HC, Krek, W, Kovacs, WJ

Cell Metab. 2014
Participants
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created
Cite Us!