NBR1 binds MAP1LC3B

Stable Identifier
R-HSA-9664867
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once recruited to the peroxisomal membrane, Next to BRCA1 gene 1 protein (NBR1) can bind with Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 with the help of its LC3 interacting region (LIR) domain (Kirkin V et al. 2009). This targets the peroxisomes to the autophagosomes and the degradation process starts.

Literature References
PubMed ID Title Journal Year
19250911 A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

Kirkin, V, Lamark, T, Sou, YS, Bjørkøy, G, Nunn, JL, Bruun, JA, Shvets, E, McEwan, DG, Clausen, TH, Wild, P, Bilusic, I, Theurillat, JP, Øvervatn, A, Ishii, T, Elazar, Z, Komatsu, M, Dikic, I, Johansen, T

Mol. Cell 2009
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created