MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1

Stable Identifier
R-HSA-9664855
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
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Sequestosome 1 (SQSTM1) is an autophagic receptor that recruits ubiquitinated cargo to the autophagosome. SQSTM1 contains a ubiquitin associated (UBA) domain that binds to monoubiquitinated Peroxisomal targeting signal 1 receptor (PEX5) in the peroxisome and an LC3 interacting region (LIR) that binds to Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 associated with the nascent autophagosome (Pankiv S et al. 2007). Subsequently, the peroxisome is degraded by the autophagy machinery.
Literature References
PubMed ID Title Journal Year
17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Pankiv, S, Clausen, TH, Lamark, T, Brech, A, Bruun, JA, Outzen, H, Øvervatn, A, Bjørkøy, G, Johansen, T

J. Biol. Chem. 2007
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as an event of
Orthologous Events
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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