MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1

Stable Identifier
R-HSA-9664855
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Sequestosome 1 (SQSTM1) is an autophagic receptor that recruits ubiquitinated cargo to the autophagosome. SQSTM1 contains a ubiquitin associated (UBA) domain that binds to monoubiquitinated Peroxisomal targeting signal 1 receptor (PEX5) in the peroxisome and an LC3 interacting region (LIR) that binds to Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 associated with the nascent autophagosome (Pankiv S et al. 2007). Subsequently, the peroxisome is degraded by the autophagy machinery.

Literature References
PubMed ID Title Journal Year
17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Bruun, JA, Clausen, TH, Pankiv, S, Lamark, T, Brech, A, Johansen, T, Øvervatn, A, Bjørkøy, G, Outzen, H

J. Biol. Chem. 2007
Participants
Input
Output
Participates
as an event of
Orthologous Events
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Bos taurus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Danio rerio)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Mus musculus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Sus scrofa)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Xenopus tropicalis)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
Cite Us!