CREB1 binds IL-10 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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The IL-10 promoter contains several transcription factor-responsive elements. (Asadullah et al 2003). In macrophages, the major source of IL-10, several receptor-mediated cytokine transcription end up in the activation of IL10 transcription factors, such as CREB (Platzer et al. 1995, Kelly et al 2010 & Sanin et al 2015)

Literature References
PubMed ID Title Journal Year
12773629 Interleukin-10 therapy--review of a new approach

Asadullah, K, Sterry, W, Volk, HD

Pharmacol. Rev. 2003
26116503 IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism

Sanin, DE, Prendergast, CT, Mountford, AP

J. Immunol. 2015
20400701 Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages

Kelly, EK, Wang, L, Ivashkiv, LB

J. Immunol. 2010
7547677 Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs

Platzer, C, Meisel, C, Vogt, K, Platzer, M, Volk, HD

Int. Immunol. 1995
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