Reactome | S-GGC MRAS G23D [plasma membrane]

S-GGC MRAS G23D [plasma membrane]

Stable Identifier

R-HSA-9660506

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ras-related protein M-Ras, RASM_HUMAN

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by MRAS-complex mutants (Homo sapiens)
      - Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
        
        Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
        
        mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
        
        S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
        
        MRAS mutants:GTP [plasma membrane] (Homo sapiens)
        
        MRAS mutants [plasma membrane] (Homo sapiens)
        
        S-GGC MRAS G23D [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14807 MRAS

Gene Names

MRAS, RRAS3

Chain

chain:1-205, propeptide:206-208

Reference Genes

BioGPS Gene:22808 MRAS

COSMIC (genes):MRAS MRAS

CTD Gene:22808 MRAS

dbSNP Gene:22808 MRAS

ENSEMBL:ENSG00000158186 MRAS

HGNC:7227 MRAS

KEGG:hsa:22808 MRAS

Monarch:22808 MRAS

NCBI Gene:22808 MRAS

OMIM:608435 MRAS

UCSC:O14807 MRAS

Reference Transcript

Other Identifiers

11716971_a_at

11758360_s_at

11758561_s_at

16946159

206538_PM_at

206538_at

225185_PM_at

225185_at

22808

2644566

2644567

2644568

2644569

2644570

2644571

2644572

2644573

2644589

2644603

2644604

2644608

2644609

2644610

2644611

2644612

2644613

2644614

2644615

2644616

2644617

38540_at

57217_at

8082965

A_14_P112094

A_14_P112544

A_14_P131120

A_23_P377197

A_24_P88850

GE54384

GO:0000166

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005886

GO:0007010

GO:0007165

GO:0007265

GO:0016020

GO:0016787

GO:0019003

GO:0030036

GO:0030742

GO:0098772

GO:1990830

HMNXSV003047674

Hs.7298.1.A1_3p_at

ILMN_1748881

PH_hs_0016853

TC03000744.hg

Participates

as a candidate of

MRAS mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

S-GGC MRAS [plasma membrane]

S-GGC MRAS T68I [plasma membrane]

S-GGC MRAS G23V [plasma membrane]

S-GGC MRAS G23R [plasma membrane]

Modified Residues

Name

S-geranylgeranyl-L-cysteine (geranylgeranyl group) at 205

Coordinate

205

Modification

geranylgeranyl group

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

L-aspartic acid 23 replaced with glycine

Coordinate

PsiMod

L-aspartic acid removal [MOD:01634]

A protein modification that effectively removes or replaces an L-aspartic acid.

glycine residue [MOD:00017]

A protein modification that effectively converts a source amino acid residue to a glycine.

Disease

Name	Identifier	Synonyms
esophageal carcinoma	DOID:1107	carcinoma OF ESOPHAGUS, carcinoma of oesophagus, cancer of esophagus, cancer of oesophagus, carcinoma of esophagus (disorder), carcinoma of esophagus (disorder)

Cross References

COSMIC

COSV56670813

ClinGen

CA354671579

OpenTargets

ENSG00000158186

ENSEMBL

ENST00000621127, ENSP00000419582, ENSP00000289104, ENSP00000418356, ENSG00000158186, ENSP00000484586, ENST00000423968, ENST00000464896, ENST00000289104, ENSP00000481637, ENST00000614350, ENST00000474559, ENSP00000389682

IntEnz

3.6.5.2

HPA

ENSG00000158186-MRAS

GeneCards

MRAS

PRO

O14807

Pharos - Targets

O14807

GlyGen

O14807

PDB

7TXH, 7TVF, 7UPI, 9C1B, 7SD0, 9C1A