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activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
Stable Identifier
R-HSA-5672723
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
Participants
components
MAPKs [cytosol]
(Homo sapiens)
p-2S MAP2K homo/heterodimers [cytosol]
(Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane]
(Homo sapiens)
RAF/MAPK scaffolds [cytosol]
(Homo sapiens)
Participates
as an input of
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
as an output of
RAF phosphorylates MAP2K dimer (Homo sapiens)
as a component of
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
Inferred To
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Bos taurus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Drosophila melanogaster)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(Sus scrofa)
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