Defective OGG1 Substrate Binding

Stable Identifier
R-HSA-9656255
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Defective OGG1 Substrate Binding
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OGG1 missense mutants reported in Alzheimer's disease, OGG1 A53T and OGG1 A288V, show decreased binding to 8 oxoguanine substrate (Mao et al. 2007).

Literature References
PubMed ID Title Journal Year
17426120 Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Huang, J, Zhang, Y, Mao, G, Pan, X, Li, GM, Markesbery, WR, Yuan, F, Lee, MP, Lovell, MA, Gu, L, Zhu, BB

Nucleic Acids Res. 2007
Participants
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-30)
Reviewed
Vlahopoulos, S  (2019-10-02)
Boldogh, I  (2019-10-08)
Created
Orlic-Milacic, M  (2019-07-30)
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