Defective Base Excision Repair Associated with OGG1

Stable Identifier
Homo sapiens
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OGG1 is the main DNA glycosylase responsible for removal of 8-oxoguanine (8oxoG), the most frequent type of oxidative DNA damage, from DNA and initiation of the base excision repair (Klungland et al. 1999, Minowa et al. 2000). A frequent OGG1 polymorphism increases the risk of breast and lung cancer in affected individuals, and inactivating mutations in OGG1 have been reported in various cancer types and in Alzheimer's disease. Ogg1 knockout mice are predisposed to cancer. For review, please refer to Boiteux et al. 2017.

Literature References
PubMed ID Title Journal Year
10725358 Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

Itoh, M, Nakai, S, Aburatani, H, Monden, Y, Minowa, O, Hippou, Y, Nishimura, S, Hirano, M, Masumura, K, Noda, T, Nohmi, T, Fukuda, M, Takano, H, Arai, T

Proc. Natl. Acad. Sci. U.S.A. 2000
27903453 Repair of 8-oxo-7,8-dihydroguanine in prokaryotic and eukaryotic cells: Properties and biological roles of the Fpg and OGG1 DNA N-glycosylases

Castaing, B, Coste, F, Boiteux, S

Free Radic. Biol. Med. 2017
10557315 Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Daly, G, Rosewell, I, Larsen, E, Lindahl, T, Epe, B, Hollenbach, S, Klungland, A, Barnes, DE, Seeberg, E

Proc. Natl. Acad. Sci. U.S.A. 1999
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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