Defective OGG1 mutants show decreased binding to 8-oxoguanine

Stable Identifier
R-HSA-9656254
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Defective OGG1 mutants show decreased binding to 8-oxoguanine
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OGG1 missense mutants reported in Alzheimer's disease, OGG1 A53T and OGG1 A288V, show decreased DNA glycosylase activity which is due to decreased binding to 8-oxoguanine substrate (Mao et al. 2007). Binding of OGG1 A53T and OGG1 A288V to 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a damaged ring-opened guanine that is also an OGG1 substrate, has not been tested.
Literature References
PubMed ID Title Journal Year
17426120 Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Huang, J, Zhang, Y, Mao, G, Pan, X, Li, GM, Markesbery, WR, Yuan, F, Lee, MP, Lovell, MA, Gu, L, Zhu, BB

Nucleic Acids Res. 2007
Participants
Input
Participates
as an event of
Normal reaction
OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)
Functional status

Loss of function of OGG1 mutants (8oxoG binding) [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-30)
Reviewed
Vlahopoulos, S  (2019-10-02)
Boldogh, I  (2019-10-08)
Created
Orlic-Milacic, M  (2019-07-30)
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