OGG1 missense mutants reported in Alzheimer's disease, OGG1 A53T and OGG1 A288V, show decreased DNA glycosylase activity which is due to decreased binding to 8-oxoguanine substrate (Mao et al. 2007). Binding of OGG1 A53T and OGG1 A288V to 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), a damaged ring-opened guanine that is also an OGG1 substrate, has not been tested.
Mao, G, Pan, X, Zhu, BB, Zhang, Y, Yuan, F, Huang, J, Lovell, MA, Lee, MP, Markesbery, WR, Li, GM, Gu, L
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