PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+

Stable Identifier
Reaction [binding]
Homo sapiens
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PDE6D binds to prenylated KRAS4B after calmodulin-stimulated dissociation from the plasma membrane (Chandra et al, 2011; Zhang et al, 2004; Weise et al, 2012; Dharmaiah et al, 2016; reviewed in Schmick et al, 2015; Baehr et al, 2014). Interaction with PDE6D may facilitate the return of KRAS4B to the plasma membrane by promoting subsequent interaction with ARL2 or ARL3 (Ismail et al, 2011; Schmick et al, 2014; Sperlich et al, 2016). This pathway counters the tendency of KRAS4B to diffuse throughout the extensive endomembrane system of the cell, in a manner analogous to the dynamic palmitoylation/depalmitoylation cycle for NRAS and HRAS (Dekker et al, 2010; Rocks et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015).
Literature References
PubMed ID Title Journal Year
20416930 The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

Chandra, A, Huang, ZP, Pechlivanis, M, Gerauer, M, Ellinger, B, Waldmann, H, Kuhlmann, J, Bastiaens, PI, Koch, S, Vartak, N, Brunsveld, L, Rocks, O

Cell 2010
20418879 Small-molecule inhibition of APT1 affects Ras localization and signaling

Waldmann, H, Bastiaens, PI, Rusch, M, Vartak, N, Brunsveld, L, Rocks, O, Coates, GW, Menninger, S, Kramer, JW, Gerauer, M, Balamurugan, R, Renner, S, Rauh, D, Schölermann, B, Dekker, FJ, Wetzel, S, Hedberg, C

Nat. Chem. Biol. 2010
27791178 Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

Dharmaiah, S, Bindu, L, Ghirlando, R, Frank, PH, McCormick, F, Gillette, WK, Tran, TH, Stephen, AG, Nissley, DV, Esposito, D, Simanshu, DK

Proc. Natl. Acad. Sci. U.S.A. 2016
22002721 Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Rusinova, A, Chandra, A, Triola, G, Bierbaum, M, Waldmann, H, Bastiaens, PI, Gremer, L, Wittinghofer, A, Chen, YX, Ismail, SA

Nat. Chem. Biol. 2011
27410739 Regulation of K-Ras4B Membrane Binding by Calmodulin

Weise, K, Waldmann, H, Winter, R, Sperlich, B, Kapoor, S

Biophys. J. 2016
24725411 KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport

Schmick, M, Rossmannek, L, Kovacevic, M, Truxius, DC, Bastiaens, PIH, Papke, B, Vartak, N

Cell 2014
25759176 Ras moves to stay in place

Schmick, M, Bastiaens, PI, Kraemer, A

Trends Cell Biol. 2015
22179043 The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

Chandra, A, Skoulidis, F, Hanzal-Bayer, M, Venkitaraman, AR, Perera, D, Cassidy, L, Bastiaens, PI, Wittinghofer, A, Ismail, SA, Grecco, HE, Pisupati, V, Hedberg, C

Nat. Cell Biol. 2011
22721555 Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: membrane delivery instead of extraction

Triola, G, Möbitz, S, Weise, K, Waldmann, H, Zimmermann, G, Winter, R, Kapoor, S, Werkmüller, A

J. Am. Chem. Soc. 2012
25550383 Membrane protein transport in photoreceptors: the function of PDEδ: the Proctor lecture

Baehr, W

Invest. Ophthalmol. Vis. Sci. 2014
14561760 Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein

Frederick, JM, Prestwich, GD, Chen, CK, Zhang, H, Baehr, W, Zhang, K, Liu, XH

J. Biol. Chem. 2004
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