Reactome | PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+

PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+

Stable Identifier

R-HSA-9654525

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PDE6D binds to prenylated KRAS4B after calmodulin-stimulated dissociation from the plasma membrane (Chandra et al, 2011; Zhang et al, 2004; Weise et al, 2012; Dharmaiah et al, 2016; reviewed in Schmick et al, 2015; Baehr et al, 2014). Interaction with PDE6D may facilitate the return of KRAS4B to the plasma membrane by promoting subsequent interaction with ARL2 or ARL3 (Ismail et al, 2011; Schmick et al, 2014; Sperlich et al, 2016). This pathway counters the tendency of KRAS4B to diffuse throughout the extensive endomembrane system of the cell, in a manner analogous to the dynamic palmitoylation/depalmitoylation cycle for NRAS and HRAS (Dekker et al, 2010; Rocks et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
20416930	The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins Rocks, O, Gerauer, M, Vartak, N, Koch, S, Huang, ZP, Pechlivanis, M, Kuhlmann, J, Brunsveld, L, Chandra, A, Ellinger, B, Waldmann, H, Bastiaens, PI	Cell	2010
20418879	Small-molecule inhibition of APT1 affects Ras localization and signaling Dekker, FJ, Rocks, O, Vartak, N, Menninger, S, Hedberg, C, Balamurugan, R, Wetzel, S, Renner, S, Gerauer, M, Schölermann, B, Rusch, M, Kramer, JW, Rauh, D, Coates, GW, Brunsveld, L, Bastiaens, PI, Waldmann, H	Nat. Chem. Biol.	2010
27791178	Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ Dharmaiah, S, Bindu, L, Tran, TH, Gillette, WK, Frank, PH, Ghirlando, R, Nissley, DV, Esposito, D, McCormick, F, Stephen, AG, Simanshu, DK	Proc. Natl. Acad. Sci. U.S.A.	2016
22002721	Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo Ismail, SA, Chen, YX, Rusinova, A, Chandra, A, Bierbaum, M, Gremer, L, Triola, G, Waldmann, H, Bastiaens, PI, Wittinghofer, A	Nat. Chem. Biol.	2011
27410739	Regulation of K-Ras4B Membrane Binding by Calmodulin Sperlich, B, Kapoor, S, Waldmann, H, Winter, R, Weise, K	Biophys. J.	2016
24725411	KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport Schmick, M, Vartak, N, Papke, B, Kovacevic, M, Truxius, DC, Rossmannek, L, Bastiaens, PIH	Cell	2014
25759176	Ras moves to stay in place Schmick, M, Kraemer, A, Bastiaens, PI	Trends Cell Biol.	2015
22179043	The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins Chandra, A, Grecco, HE, Pisupati, V, Perera, D, Cassidy, L, Skoulidis, F, Ismail, SA, Hedberg, C, Hanzal-Bayer, M, Venkitaraman, AR, Wittinghofer, A, Bastiaens, PI	Nat. Cell Biol.	2011
22721555	Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: membrane delivery instead of extraction Weise, K, Kapoor, S, Werkmüller, A, Möbitz, S, Zimmermann, G, Triola, G, Waldmann, H, Winter, R	J. Am. Chem. Soc.	2012
25550383	Membrane protein transport in photoreceptors: the function of PDEδ: the Proctor lecture Baehr, W	Invest. Ophthalmol. Vis. Sci.	2014
14561760	Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein Zhang, H, Liu, XH, Zhang, K, Chen, CK, Frederick, JM, Prestwich, GD, Baehr, W	J. Biol. Chem.	2004