RAS processing

Stable Identifier
R-HSA-9648002
DOI
10.3180/R-HSA-9648002.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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RAS processing
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RAS proteins undergo several processing steps during maturation including farnesylation, carboxy-terminal cleavage and carboxymethylation, among others. These steps are required for their membrane localization and function and ultimately for their ability to activate RAF (reviewed in Gysin et al, 2011; Ahearn et al, 2018).
Literature References
PubMed ID Title Journal Year
21779505 Therapeutic strategies for targeting ras proteins

McCormick, F, Salt, M, Young, A, Gysin, S

Genes Cancer 2011
29311131 Posttranslational Modifications of RAS Proteins

Philips, MR, Zhou, M, Ahearn, I

Cold Spring Harb Perspect Med 2018
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Orthologous Events
RAS processing (Bos taurus)
RAS processing (Caenorhabditis elegans)
RAS processing (Canis familiaris)
RAS processing (Danio rerio)
RAS processing (Dictyostelium discoideum)
RAS processing (Drosophila melanogaster)
RAS processing (Gallus gallus)
RAS processing (Mus musculus)
RAS processing (Plasmodium falciparum)
RAS processing (Rattus norvegicus)
RAS processing (Saccharomyces cerevisiae)
RAS processing (Schizosaccharomyces pombe)
RAS processing (Sus scrofa)
RAS processing (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Rothfels, K  (2019-10-25)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2019-06-04)
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