ARL2:GTP binds to an allosteric site on PDE6D, promoting a conformational change in PDE6D that releases the prenyl group on KRAS4B (Ismail et al, 2011; Schmick et al, 2014; reviewed in Schmick et al, 2015). Although the details remain to be fully established, it is possible that after release from PDE6D, KRAS4B is recycled to the plasma membrane by virtue of interaction with the negatively charged membrane of recyling endosomes (Chen et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015).
Rusinova, A, Chandra, A, Triola, G, Bierbaum, M, Waldmann, H, Bastiaens, PI, Gremer, L, Wittinghofer, A, Chen, YX, Ismail, SA
Schmick, M, Rossmannek, L, Kovacevic, M, Truxius, DC, Bastiaens, PIH, Papke, B, Vartak, N
Schmick, M, Bastiaens, PI, Kraemer, A
Yan, J, Li, X, Zhang, Y, Zeng, S, Chen, B, Zou, W, Wang, X, Jiang, Y
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