Reactome | ARL2:GTP bind PDE6D on KRAS4B

ARL2:GTP bind PDE6D on KRAS4B

Stable Identifier

R-HSA-9654523

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ARL2:GTP binds to an allosteric site on PDE6D, promoting a conformational change in PDE6D that releases the prenyl group on KRAS4B (Ismail et al, 2011; Schmick et al, 2014; reviewed in Schmick et al, 2015). Although the details remain to be fully established, it is possible that after release from PDE6D, KRAS4B is recycled to the plasma membrane by virtue of interaction with the negatively charged membrane of recyling endosomes (Chen et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
22002721	Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo Rusinova, A, Chandra, A, Triola, G, Bierbaum, M, Waldmann, H, Bastiaens, PI, Gremer, L, Wittinghofer, A, Chen, YX, Ismail, SA	Nat. Chem. Biol.	2011
24725411	KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport Schmick, M, Rossmannek, L, Kovacevic, M, Truxius, DC, Bastiaens, PIH, Papke, B, Vartak, N	Cell	2014
25759176	Ras moves to stay in place Schmick, M, Bastiaens, PI, Kraemer, A	Trends Cell Biol.	2015
21170358	Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1 Yan, J, Li, X, Zhang, Y, Zeng, S, Chen, B, Zou, W, Wang, X, Jiang, Y	PLoS Genet.	2010