ARL2:GTP bind PDE6D on KRAS4B

Stable Identifier
R-HSA-9654523
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ARL2:GTP binds to an allosteric site on PDE6D, promoting a conformational change in PDE6D that releases the prenyl group on KRAS4B (Ismail et al, 2011; Schmick et al, 2014; reviewed in Schmick et al, 2015). Although the details remain to be fully established, it is possible that after release from PDE6D, KRAS4B is recycled to the plasma membrane by virtue of interaction with the negatively charged membrane of recyling endosomes (Chen et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015).

Literature References
PubMed ID Title Journal Year
24725411 KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport

Schmick, M, Vartak, N, Papke, B, Kovacevic, M, Truxius, DC, Rossmannek, L, Bastiaens, PIH

Cell 2014
22002721 Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Ismail, SA, Chen, YX, Rusinova, A, Chandra, A, Bierbaum, M, Gremer, L, Triola, G, Waldmann, H, Bastiaens, PI, Wittinghofer, A

Nat. Chem. Biol. 2011
25759176 Ras moves to stay in place

Schmick, M, Kraemer, A, Bastiaens, PI

Trends Cell Biol. 2015
21170358 Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1

Chen, B, Jiang, Y, Zeng, S, Yan, J, Li, X, Zhang, Y, Zou, W, Wang, X

PLoS Genet. 2010
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